Scientist II (Oligonucleotide Synthesis)

Our client, a world leader in biotechnology and life sciences, is looking for an “Scientist II (Oligonucleotide Synthesis)” based in South San Francisco, CA.

Job Duration: Long Term Contract (Possibility Of Extension)
Rate: $51/hr on W2
Company Benefits: Medical, Dental, Vision, Paid Sick leave, 401K

Overview
This role focuses on oligonucleotide therapeutics discovery, supporting RNAi-based research through synthesis, characterization, and collaboration across therapeutic areas.

Key Responsibilities

• Design and execute oligonucleotide synthesis and purification workflows.
• Perform HPLC and mass spectrometer analysis for characterization and impurity profiling.
• Support RNAi and nucleic acid therapeutic discovery across neuroscience, immunology, and oncology programs.
• Develop and scale up synthesis of lead oligonucleotide candidates for pre clinical studies.
• Collaborate with cross-functional teams to integrate chemistry and biology data.
• Maintain and troubleshoot lab equipment (e.g., oligo synthesizers, HPLC systems).
• Conduct literature reviews and contribute to experimental design and strategy.

Qualifications

• BS/MS in Organic Chemistry or related field.
• Hands-on experience with oligonucleotide synthesis, purification, and characterization.
• Experience with automated oligo synthesizers, HPLC, and mass spectrometry.
• Understanding of RNAi, nucleic acid therapeutics, and modification chemistries preferred.

If interested, please send us your updated resume at [email protected]/[email protected].