Research Associate-II/Senior Research Associate, Histology
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SonoThera
South San Francisco, CA, US
Summary
The Research Associate will perform histological procedures including processing, embedding, and sectioning tissue samples to support gene therapy programs. They will also conduct specialized staining, image analysis, and maintain accurate study records in the electronic lab notebook.
Job Description
About SonoThera:
SonoThera is a venture-backed genetic medicine company advancing ultrasound-mediated, non-viral targeted therapies to unlock the full potential of genetic medicines. Our platform is designed to overcome key limitations in the field, enabling precise, redosable delivery across a broad range of diseases with high unmet need. Headquartered in South San Francisco, SonoThera brings together a world-class, interdisciplinary team focused on translating breakthrough science into transformative therapies.
The Role:
The Bioanalytical group at SonoThera is seeking to hire an enthusiastic (Senior) Research Associate to support gene therapy drug development by performing histological procedures. We seek candidates who think critically and have the desire and ability to learn new techniques. This position requires adaptability and an ability to perform at a high level in a fast-paced environment. This position is 100% on-site and requires working from the office Monday through Friday. The role reports to the Sr. Director, Vivarium Operations & Bioanalytics.
What You Will Do:
In this position, you will play an integral role in histology analysis by preparing and evaluating biological tissue samples that support biomarker assessment and gene therapy programs. You will partner with teams across the organization to receive mouse, rat, and NHP tissue samples and to:
- Process, embed, and section FFPE and fresh frozen tissue samples.
- Perform routine and specialized staining, including H&E, PAS, Trichrome, ISH, IHC, and IF.
- Image stained slides and support qualitative and quantitative assessment of results.
- Track sample accessioning, inventory, and chain of custody in the electronic lab notebook.
- Document methods and results in SOPs and study records, and contribute to assay optimization.
What You Will Bring:
Technical Requirements & Skills:
- Advanced proficiency in FFPE tissue processing, embedding and sectioning and in mounting and cryosectioning of fresh frozen samples for a variety of tissues and species.
- Experience preparing slides for DNA and RNA analysis (RNAscope, Visium, etc.) is a plus.
- Experience performing routine stains such as H&E, PAS, and Masson’s Trichrome
- Experience performing specialized stains such as IHC and ISH using autostainers such as Leica Bond RX, Ventana or similar. Optimizing antibodies for IHC/IF is a plus.
- Experience using imaging platforms such as VS200, 3dhistec P150/P250, Aperio Imagescope, Revolve or similar
- Experience using image analysis platforms such as HALO, Visiopharm or similar is a plus
- Training or hands-on experience in sample management workflows.
- Exceptional organizational skills including SOP documentation and record-keeping using ELN platforms such as Benchling.
- Demonstrated commitment to laboratory safety and regulatory compliance.
Qualifications:
- Bachelor’s degree in biology, biomedical science, or a related field, with at least 2 years of relevant laboratory experience.
- Strong communication, critical thinking, and problem-solving skills.
- Industry experience preferred.
Compensation:
The salary range for this position is $87, 000 to $100, 000 USD per year. This annual salary range is an estimate, and the actual salary may vary based on various factors, including, without limitation, individual education, experience, tenure, skills, and abilities, as well as internal equity and alignment with market data, including potential adjustments for geographic location.
Benefits:
We offer our employees a comprehensive benefits package.
At SonoThera, we'll give you the tools to feel healthy, happy and secure.
🏋🏻 Access to a 24-hour onsite gym
💝 Comprehensive medical, dental, and vision
💰 Equity and ownership in a fast-growing company
🚗 Commuting stipend based on your geographical location
🏦 401(k) Match: SonoThera offers a company match
🏝 All full-time employees are eligible for our flexible time off policy
Equal Opportunity for Diversity & Inclusion
SonoThera provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
